Synthesis of isoxazolidino analogues of 2',3'-dideoxynucleosides

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):581-3. doi: 10.1080/15257779908041501.

Abstract

The complete set of the 4'-aza analogues of 2',3'-dideoxynucleosides was synthesized by cycloaddition of N-tetrahydropiranyl or N-trityl methylene nitrones on suitably protected vinyl nucleobases. The convertible nucleoside approach was used in the preparation of cytosine and 5-methyl cytosine analogues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dideoxynucleosides / chemical synthesis*
  • Dideoxynucleosides / chemistry
  • Magnetic Resonance Spectroscopy
  • Nucleic Acid Conformation
  • Oxazoles / chemistry
  • Spectrometry, Mass, Fast Atom Bombardment

Substances

  • Dideoxynucleosides
  • Oxazoles