Synthesis and biological activity of 5-azacytosine nucleosides derived from 4-thio-2-deoxy-L-threo-pentofuranose and 4-thio-2-deoxy-D-erythro-pentofuranose

L Cappellacci; K N Tiwari; J A Montgomery; J A Secrist 3rd

doi:10.1080/15257779908041514

Synthesis and biological activity of 5-azacytosine nucleosides derived from 4-thio-2-deoxy-L-threo-pentofuranose and 4-thio-2-deoxy-D-erythro-pentofuranose

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):613-4. doi: 10.1080/15257779908041514.

Authors

L Cappellacci¹, K N Tiwari, J A Montgomery, J A Secrist 3rd

Affiliation

¹ Southern Research Institute, Birmingham, AL 35255-5305, USA.

PMID: 10432653
DOI: 10.1080/15257779908041514

Abstract

1-O-Acetyl-2-deoxy-3,5-di-O-toluoyl-4-thio-D-erythro-pentofuranose and 2-deoxy-1,3,5-tri-O-acetyl-4-thio-L-threo-pentofuranose were coupled with 5-azacytosine to obtain alpha and beta anomers of nucleosides.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cytosine / analogs & derivatives*
Cytosine / chemical synthesis
Cytosine / chemistry
Cytosine / pharmacology
Drug Screening Assays, Antitumor
Hepatitis B virus / drug effects
Humans
Pentoses / chemistry*
Tumor Cells, Cultured

Substances

4-thio-2-deoxy-pentofuranose
Antineoplastic Agents
Pentoses
5-azacytosine
Cytosine