Synthesis and antiviral activities of 1,3-oxathiolanyl nucleosides with 5-hydroxymethyl substituent

M W Chun; S P Choi; M J Kim; C J Bae; H R Moon; H D Kim; L S Jeong

doi:10.1080/15257779908041515

Synthesis and antiviral activities of 1,3-oxathiolanyl nucleosides with 5-hydroxymethyl substituent

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):615-6. doi: 10.1080/15257779908041515.

Authors

M W Chun¹, S P Choi, M J Kim, C J Bae, H R Moon, H D Kim, L S Jeong

Affiliation

¹ College of Pharmacy, Seoul National University, Korea.

PMID: 10432654
DOI: 10.1080/15257779908041515

Abstract

Novel 1,3-oxathiolanyl pyrimidine nucleosides with 5-hydroxymethyl substituent were synthesized starting from D-mannose and evaluated for antiviral activities against HIV-1, HSV type 1,2 and HCMV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology*
HIV-1 / drug effects
Herpesviridae / drug effects
Microbial Sensitivity Tests
Nucleosides / chemical synthesis*
Nucleosides / pharmacology*

Substances

Antiviral Agents
Nucleosides