Abstract
A systematic search was performed for DNA sequence variation in genes regulating neurotransmitter metabolism in rhesus macaque (Macaca mulatta). These genes included dopamine and serotonin receptors and transporters, and tyrosine hydroxylase. A total of 13 single nucleotide polymorphisms in five different genes were identified, namely: DRD1 (-244T->G), q = 0.45; DRD1 (-179C->T), q = 0.19; DRD1 (-127G->A), q = 0.25; DRD1(-11T->G), q = 0.08; DRD1(-81C->T), q = 0.19; DRD3 (248G->A), q= 0.08; DRD3(341G->C), q = 0.11; DRD3(377A->G), q = 0.19; DRD3 (403C->T; A59V), q= 0.11; DRD4(2608G->A), q= 0.48; HTR1D(-506G->T), q = 0.47; HTR1D(-173C->T), q = 0.47; and HTT(340G->A), q = 0.39. The nucleotide positions listed correspond to the human homologs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Animals
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Base Sequence
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Carrier Proteins / genetics
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DNA / genetics*
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DNA Primers
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Dopamine / metabolism*
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Dopamine Plasma Membrane Transport Proteins
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Gene Frequency
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Haplotypes
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Humans
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Macaca mulatta / genetics*
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Macaca mulatta / metabolism
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Membrane Glycoproteins / genetics
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Membrane Transport Proteins*
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Nerve Tissue Proteins*
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Polymerase Chain Reaction
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Polymorphism, Genetic*
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Receptors, Dopamine / genetics
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Receptors, Serotonin / genetics
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Serotonin / metabolism*
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Serotonin Plasma Membrane Transport Proteins
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Tyrosine 3-Monooxygenase / genetics
Substances
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Carrier Proteins
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DNA Primers
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Receptors, Dopamine
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Receptors, Serotonin
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Serotonin
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DNA
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Tyrosine 3-Monooxygenase
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Dopamine