Histone acetylation in signal transduction by growth regulatory signals

Semin Cell Dev Biol. 1999 Apr;10(2):197-203. doi: 10.1006/scdb.1999.0301.

Abstract

Cell fate is determined by extracellular signals which are transmitted to the nucleus and result in the transcriptional regulation of specific subsets of genes. Transcriptional regulation has been recently linked to enzymatic activities which are able to acetylate or deacetylate core histone tails. A number of transcriptional co-regulators are histone acetyl-transferases or histone deacetylases. Here, we discuss the involvement of these enzymes in critical steps of cell proliferation or cell differentiation control

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation
  • Acetyltransferases / physiology*
  • Animals
  • Carrier Proteins*
  • Cell Cycle
  • Cell Cycle Proteins*
  • Cell Differentiation
  • Cell Division
  • Cell Transformation, Neoplastic
  • Chromatin / metabolism
  • DNA-Binding Proteins*
  • E2F Transcription Factors
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / physiology*
  • Growth Substances / pharmacology
  • Growth Substances / physiology*
  • Histone Acetyltransferases
  • Histone Deacetylases / physiology*
  • Histones / metabolism*
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Protein Processing, Post-Translational* / drug effects
  • Receptors, Retinoic Acid / drug effects
  • Receptors, Retinoic Acid / physiology
  • Retinoblastoma Protein / physiology
  • Retinoblastoma-Binding Protein 1
  • Saccharomyces cerevisiae Proteins*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology*
  • Transcription Factor DP1
  • Transcription Factors / metabolism
  • Transcription, Genetic / physiology
  • Tretinoin / pharmacology

Substances

  • Arid4a protein, mouse
  • Carrier Proteins
  • Cell Cycle Proteins
  • Chromatin
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Growth Substances
  • Histones
  • Receptors, Retinoic Acid
  • Retinoblastoma Protein
  • Retinoblastoma-Binding Protein 1
  • Saccharomyces cerevisiae Proteins
  • Transcription Factor DP1
  • Transcription Factors
  • Tretinoin
  • Acetyltransferases
  • Histone Acetyltransferases
  • Histone Deacetylases