Evaluation of the neurovirulence test for mumps vaccines

Biologicals. 1999 Mar;27(1):43-9. doi: 10.1006/biol.1999.0174.

Abstract

Neurovirulence tests in Macaca fascicularis using commercial preparations of different vaccine bulks and a wild-type strain revealed that the test was unable to distinguish mixed from pure populations or a suitable vaccine from a related strain which has been shown to be associated with clinical meningitis. However, the test was able to distinguish a wild-type strain from the vaccine strains successfully. The ability of the test to discriminate between acceptable and unacceptable seeds requires further examination.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Brain / pathology
  • Brain / virology
  • Cerebral Ventricles / pathology
  • Cerebral Ventricles / virology
  • Chlorocebus aethiops
  • Humans
  • Macaca fascicularis
  • Mumps Vaccine / administration & dosage
  • Mumps Vaccine / standards*
  • Mumps virus / pathogenicity
  • Serologic Tests
  • Severity of Illness Index
  • Vero Cells
  • Virulence

Substances

  • Mumps Vaccine