Abstract
A small set of 9-(lupinylthio)xanthene, -thioxanthenes and alpha-(lupinylthio)diphenylmethanes was prepared and found to inhibit the angiotensin II-induced contractions of guinea pig ileum. Some of these compounds were also moderately active in vitro as tracheal relaxants and one compound was more active than aspirin against arachidonic acid-induced platelet aggregation.
MeSH terms
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Adrenal Glands / drug effects
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Adrenal Glands / metabolism
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Angiotensin II / antagonists & inhibitors*
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Animals
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Binding, Competitive / drug effects
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Guinea Pigs
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In Vitro Techniques
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects*
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Platelet Aggregation Inhibitors / chemical synthesis*
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Platelet Aggregation Inhibitors / pharmacology
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Quinolizines / chemistry*
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Rabbits
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Spectrophotometry, Ultraviolet
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Trachea / drug effects*
Substances
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Platelet Aggregation Inhibitors
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Quinolizines
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Angiotensin II
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thiolupinine