Hepatocellular carcinoma in a patient with hereditary hemochromatosis and noncirrhotic liver. A case report

Pathol Res Pract. 1999;195(7):509-13. doi: 10.1016/S0344-0338(99)80055-7.

Abstract

A case of a 62-year-old patient with hereditary hemochromatosis is reported, who developed hepatocellular carcinoma (HCC) in the absence of cirrhosis and other potential risk factors for HCC. Occurrence of HCC in patients with genetic hemochromatosis and noncirrhotic liver is a rare event which has previously been described only six times and appears to be limited to male patients.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Hepatocellular / complications*
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / pathology*
  • HLA Antigens / genetics
  • HLA Antigens / metabolism
  • Hemochromatosis / complications*
  • Hemochromatosis / genetics
  • Hemochromatosis Protein
  • Hemosiderin / metabolism
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Iron / metabolism
  • Liver Neoplasms / complications*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / pathology*
  • Male
  • Membrane Proteins*
  • Middle Aged

Substances

  • HFE protein, human
  • HLA Antigens
  • Hemochromatosis Protein
  • Histocompatibility Antigens Class I
  • Membrane Proteins
  • Hemosiderin
  • Iron