Molecular regulation of cell death and therapeutic strategies for cell death induction in prostate carcinoma

B T Gjertsen; C J Logothetis; T J McDonnell

doi:10.1023/a:1006170332301

Molecular regulation of cell death and therapeutic strategies for cell death induction in prostate carcinoma

Cancer Metastasis Rev. 1998;17(4):345-51. doi: 10.1023/a:1006170332301.

Authors

B T Gjertsen¹, C J Logothetis, T J McDonnell

Affiliation

¹ Department of Molecular Pathology, University of Texas M.D. Anderson Cancer Center, Houston, USA.

PMID: 10453278
DOI: 10.1023/a:1006170332301

Abstract

Many of the common molecular alterations associated with prostate cancer progression involve genes known to regulate cell death susceptibility. The significance of these molecular events is discussed in the context of developing and implementing new strategies designed to restore cell death susceptibility in prostate cancer cells and overcome therapeutic resistance.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apoptosis
Cell Death / genetics
Cell Death / physiology*
Genetic Therapy
Humans
Male
Prostatic Neoplasms / genetics
Prostatic Neoplasms / metabolism
Prostatic Neoplasms / pathology
Prostatic Neoplasms / therapy*
Proto-Oncogene Proteins / physiology
Proto-Oncogene Proteins c-bcl-2 / biosynthesis
Proto-Oncogene Proteins c-bcl-2 / metabolism
Proto-Oncogene Proteins c-bcl-2 / physiology
Tumor Suppressor Protein p53 / physiology
bcl-2-Associated X Protein

Substances

Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Tumor Suppressor Protein p53
bcl-2-Associated X Protein