The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

Int J Obes Relat Metab Disord. 1999 Jun;23 Suppl 6(Suppl 6):S49-50. doi: 10.1038/sj.ijo.0800945.

Abstract

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3> have been described in humans, but not in rodents. The functional consequences-or lack thereof-of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Energy Metabolism / genetics
  • Energy Metabolism / physiology*
  • Exons
  • Homeostasis
  • Humans
  • Ion Channels
  • Mitochondria / physiology*
  • Mitochondrial Proteins
  • Mutation
  • Obesity / genetics
  • Obesity / physiopathology
  • Uncoupling Protein 3

Substances

  • Carrier Proteins
  • Ion Channels
  • Mitochondrial Proteins
  • UCP3 protein, human
  • Uncoupling Protein 3