The role of early renal biopsy in cyclosporin induced thrombotic microangiopathy

Pediatr Nephrol. 1999 Sep;13(7):564-6. doi: 10.1007/s004670050743.

Abstract

Thrombotic microangiopathy is an uncommon complication of cyclosporin immunosuppression following renal transplantation. We present a 15-year-old girl who developed clinical features of acute rejection, but in whom an early biopsy revealed thrombotic microangiopathy, allowing a change to FK506 immunosuppression resulting in excellent graft recovery.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Biopsy
  • Capillaries / pathology
  • Cyclosporine / adverse effects*
  • Female
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Kidney / pathology*
  • Kidney Glomerulus / blood supply*
  • Retreatment
  • Tacrolimus / therapeutic use
  • Thrombosis / chemically induced*
  • Thrombosis / pathology*

Substances

  • Immunosuppressive Agents
  • Cyclosporine
  • Tacrolimus