Transmission of a Y chromosomal deletion involving the deleted in azoospermia (DAZ) and chromodomain (CDY1) genes from father to son through intracytoplasmic sperm injection: case report

A Kamischke; J Gromoll; M Simoni; H M Behre; E Nieschlag

doi:10.1093/humrep/14.9.2320

Transmission of a Y chromosomal deletion involving the deleted in azoospermia (DAZ) and chromodomain (CDY1) genes from father to son through intracytoplasmic sperm injection: case report

Hum Reprod. 1999 Sep;14(9):2320-2. doi: 10.1093/humrep/14.9.2320.

Authors

A Kamischke¹, J Gromoll, M Simoni, H M Behre, E Nieschlag

Affiliation

¹ Institute of Reproductive Medicine and Department of Obstetrics and Gynaecology of the University, Domagkstr. 11, D-48129 Münster, Germany.

PMID: 10469702
DOI: 10.1093/humrep/14.9.2320

Abstract

The transmission of a deleted in azoospermia (DAZ) deletion from a severely oligozoospermic patient to his son following intracytoplasmic sperm injection (ICSI) treatment is reported. The case report highlights the fertilizing capacity of spermatozoa carrying Y chromosome deletions in patients treated with ICSI and stresses the importance of genetic counselling in severe male infertility.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Deleted in Azoospermia 1 Protein
Fertilization in Vitro / methods*
Gene Deletion*
Genetic Counseling
Humans
Male
Microinjections
Nuclear Proteins*
Proteins / genetics*
RNA-Binding Proteins / genetics*
Sex Chromosome Aberrations / genetics*
Y Chromosome*

Substances

CDY1 protein, human
CDY2A protein, human
DAZ1 protein, human
Deleted in Azoospermia 1 Protein
Nuclear Proteins
Proteins
RNA-Binding Proteins