The TBP-like factor: an alternative transcription factor in metazoa?

Trends Biochem Sci. 1999 Sep;24(9):335-9. doi: 10.1016/s0968-0004(99)01436-x.

Abstract

Protein sequence analysis has revealed a family of TATA-binding-protein (TBP)-like factors (TLFs) in metazoan organisms. Modelling of the three-dimensional structure of these TLFs suggests that they form an asymmetric saddle-like structure and that, unlike TBP, TLFs might bind to DNA sequences other than classical TATA boxes. Thus, the existence of TLFs presents a challenge to the doctrine that TBP is a universal regulator of transcription in metazoans.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Caenorhabditis elegans / chemistry
  • Conserved Sequence
  • DNA Polymerase II / metabolism
  • DNA-Binding Proteins / chemistry*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Databases, Factual
  • Evolution, Molecular
  • Invertebrates / genetics*
  • Models, Molecular
  • Molecular Sequence Data
  • Phylogeny
  • Protein Conformation
  • Sequence Homology, Amino Acid
  • Substrate Specificity
  • TATA Box Binding Protein-Like Proteins
  • TATA-Box Binding Protein
  • Transcription Factors / chemistry*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Vertebrates / genetics

Substances

  • DNA-Binding Proteins
  • TATA Box Binding Protein-Like Proteins
  • TATA-Box Binding Protein
  • Transcription Factors
  • DNA Polymerase II

Associated data

  • GENBANK/AJ238441
  • GENBANK/AJ238443
  • GENBANK/AJ238444