Recently, the Seaman Family Magnetic Resonance Research Center, Calgary, Alberta, Canada, unveiled leading technology with its moveable intraoperative magnetic resonance imaging (MRI) system. The new system, which is housed in the OR, allows surgeons to use well-established neurosurgical techniques and instrumentation with the convenience of moving the high-resolution magnet in and out of the surgical field at any time. This mobility provides surgical team members with updated images that are vital to ensuring quality and determining the effect of surgery on brain structure and function. Based on experiences with the first 48 patients, this article describes the intraoperative MRI method and provides pertinent guidelines for safe perioperative care using this innovative MRI system.