Abstract
A series of indolo[3,2-c]cinnoline derivatives was prepared and tested to evaluate their biological activity. Most of them inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations, whereas none of the compounds were active against HIV-1. With the exception of 7g, all title compounds showed antibacterial activity against gram-positive bacteria, being up to 200 times more potent than the reference drug streptomycin. Some of the indolo[3,2-c]cinnolines were also endowed with good antifungal activity, particularly against Criptococcus neoformans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Division / drug effects
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Cryptococcus neoformans / drug effects
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Humans
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Indoles / chemistry
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Indoles / pharmacology*
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Microbial Sensitivity Tests
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Phthalazines / chemistry
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Phthalazines / pharmacology*
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Tumor Cells, Cultured
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Antineoplastic Agents
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Indoles
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Phthalazines