Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants

F Aspesberro; M Beghetti; I Oberhänsli; H Ozsahin; J Humbert; P C Rimensberger

doi:10.1007/s004310051182

Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants

Eur J Pediatr. 1999 Sep;158(9):698-701. doi: 10.1007/s004310051182.

Authors

F Aspesberro¹, M Beghetti, I Oberhänsli, H Ozsahin, J Humbert, P C Rimensberger

Affiliation

¹ Critical Care, Cardiology and Hematology-Oncology, Department of Pediatrics, Hôspital des Enfants, University Hospital of Geneva, Switzerland.

PMID: 10485298
DOI: 10.1007/s004310051182

Abstract

We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects. This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy.

Publication types

Case Reports

MeSH terms

Female
Heart Atria / diagnostic imaging
Heart Diseases / drug therapy*
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*
Infant, Very Low Birth Weight
Male
Plasminogen Activators / administration & dosage*
Plasminogen Activators / therapeutic use
Risk Factors
Thrombolytic Therapy / methods
Thrombosis / drug therapy*
Treatment Outcome
Ultrasonography
Urokinase-Type Plasminogen Activator / administration & dosage*
Urokinase-Type Plasminogen Activator / therapeutic use

Substances

Plasminogen Activators
Urokinase-Type Plasminogen Activator