Abstract
Pharmacotoxicological properties of ximedone, a new pyrimidine derivative, were studied experimentally on animals of various species. In the enteral regimen the drug had a favourable effect on thermal burns and postoperative cutaneous and gastric wounds. The results enabled to recommend ximedone for the clinical practice.
MeSH terms
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Adjuvants, Immunologic / therapeutic use*
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Adjuvants, Immunologic / toxicity
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Animals
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Burns / drug therapy*
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Drug Evaluation, Preclinical
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Guinea Pigs
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Lethal Dose 50
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Mice
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Postoperative Complications / prevention & control
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Pyrimidines / therapeutic use*
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Pyrimidines / toxicity
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Rabbits
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Rats
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Rats, Wistar
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Surgical Wound Infection / drug therapy*
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Wound Healing / drug effects
Substances
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Adjuvants, Immunologic
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Pyrimidines
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xymedon