Relevance of glutamate levels in the CSF of patients with HIV-1-associated dementia complex

M G Espey; R J Ellis; R K Heaton; A S Basile

doi:10.1212/wnl.53.5.1144

Relevance of glutamate levels in the CSF of patients with HIV-1-associated dementia complex

Neurology. 1999 Sep 22;53(5):1144-5. doi: 10.1212/wnl.53.5.1144.

Authors

M G Espey¹, R J Ellis, R K Heaton, A S Basile

Affiliation

¹ Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 10496286
DOI: 10.1212/wnl.53.5.1144

Abstract

Chronic hyperactivation of excitatory amino acid pathways in the CNS of patients infected with HIV-1 may contribute to the pathogenesis of HIV-1-associated dementia complex. However, no correlation between the concentration of glutamate in CSF (mean 3.3 micromol/L) and either HIV-1 infection or HIV-1-associated dementia complex was observed. The results clarify several important issues regarding analysis of glutamate in the CSF and the role of excitotoxins in HIV-1-associated dementia complex.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

AIDS Dementia Complex / cerebrospinal fluid*
Chromatography, High Pressure Liquid
Female
Glutamic Acid / cerebrospinal fluid*
HIV-1*
Humans
Male

Substances

Glutamic Acid

Abstract

Publication types

MeSH terms

Substances

Grants and funding