Abstract
Herein, the genetic control of regionalization and connectivity of the neocortex are reviewed. Evidence is accumulating which suggests that intrinsic mechanisms have a central role in controlling cortical regional specification and differentiation. Expression patterns of several genes (Id-2, Tbr-1, cadherin-6, cadherin-8, neuropilin-2, Wnt-7b, Eph-A7 and RZR-beta) are described; the expressions of these genes have regional boundaries which demarcate distinct functional areas of the cerebral cortex in neonatal mice.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Newborn
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Axons / chemistry
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Axons / physiology
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Biomarkers
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Brain Stem / cytology
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Cadherins / genetics
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DNA-Binding Proteins / genetics
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Gene Expression Regulation, Developmental*
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Glycoproteins*
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Inhibitor of Differentiation Protein 2
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Mice
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Mice, Inbred Strains
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Neocortex / cytology*
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Neocortex / embryology*
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Neocortex / growth & development
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Nerve Tissue Proteins / genetics
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Neural Pathways / cytology*
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Neural Pathways / embryology*
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Neural Pathways / growth & development
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Neuropilin-1
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Proto-Oncogene Proteins / genetics
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RNA, Messenger / analysis
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Receptor Protein-Tyrosine Kinases / genetics
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Receptor, EphA7
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Receptors, Cell Surface / genetics
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Receptors, Cytoplasmic and Nuclear / genetics
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Receptors, Melatonin
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Repressor Proteins*
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Spinal Cord / cytology
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T-Box Domain Proteins
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Thalamus / cytology
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Transcription Factors*
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Wnt Proteins
Substances
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Biomarkers
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Cadherins
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Cdh8 protein, mouse
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DNA-Binding Proteins
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Glycoproteins
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Idb2 protein, mouse
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Inhibitor of Differentiation Protein 2
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Nerve Tissue Proteins
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Proto-Oncogene Proteins
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RNA, Messenger
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Receptors, Cell Surface
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Receptors, Cytoplasmic and Nuclear
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Receptors, Melatonin
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Repressor Proteins
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T-Box Domain Proteins
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Tbr1 protein, mouse
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Transcription Factors
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Wnt Proteins
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Wnt7b protein, mouse
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Neuropilin-1
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Receptor Protein-Tyrosine Kinases
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Receptor, EphA7
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K cadherin