Abstract
This review of the molecules and pathways involved in programmed cell death (apoptosis) discriminates triggers of apoptosis (e.g. chemotherapy, radiation, Fas ligation), modulators of apoptosis (e.g. Bcl-2 family members, Bcl-2 interacting proteins, Apafs, IAPs, and Fas/FasL modulators including FLICE and FLIPs), effectors (caspases 1-13) and cleavage substrates (e.g. PARP). Special consideration is given to the structure-function relationship of Bcl-2 family members and to their post-transcriptional modification. Brief references are made to the role of apoptotic pathway in leukemias and lymphomas and to strategies of modulating apoptotic pathways.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis / genetics
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Apoptosis / physiology*
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CASP8 and FADD-Like Apoptosis Regulating Protein
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Carrier Proteins / metabolism
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Caspase 8
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Caspase 9
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Caspases / metabolism
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Fas Ligand Protein
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Humans
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Intracellular Signaling Peptides and Proteins*
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Leukemia / pathology*
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Leukemia / physiopathology
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Lymphoma / pathology*
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Lymphoma / physiopathology
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Membrane Glycoproteins / physiology
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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fas Receptor / physiology
Substances
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CASP8 and FADD-Like Apoptosis Regulating Protein
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CFLAR protein, human
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Carrier Proteins
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FASLG protein, human
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Fas Ligand Protein
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Intracellular Signaling Peptides and Proteins
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Membrane Glycoproteins
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Proto-Oncogene Proteins c-bcl-2
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fas Receptor
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CASP8 protein, human
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CASP9 protein, human
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Caspase 8
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Caspase 9
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Caspases