Melanotic peritoneal sarcomatosis originating from clear cell sarcoma

Pathol Int. 1999 Jul;49(7):653-7. doi: 10.1046/j.1440-1827.1999.00916.x.

Abstract

Peritoneal sarcomatosis was found in a 53-year-old male who had a history of resection of clear cell sarcoma (CCS) of the right wrist 7 years previously. Both the previous wrist tumor and the peritoneal disseminants consisted of small, spindle-shaped cells occasionally containing melanophages. Histologic features, histochemical demonstration of argentaffin granules, immunohistochemical reaction with HMB 45, and the demonstration of a chimeric transcript of EWS-ATF-1 established the diagnosis of CCS in the peritoneal tumors. As far as we are aware, this is the first case of a peritoneal sarcomatosis associated with CCS.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Neoplasm / analysis
  • DNA Primers / chemistry
  • DNA, Neoplasm / analysis
  • Fatal Outcome
  • Humans
  • Male
  • Melanocytes / chemistry
  • Melanocytes / pathology*
  • Melanoma-Specific Antigens
  • Middle Aged
  • Neoplasm Proteins / analysis
  • Oncogene Proteins, Fusion / analysis
  • Peritoneal Neoplasms / chemistry
  • Peritoneal Neoplasms / secondary*
  • Peritoneum
  • RNA Splicing
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sarcoma, Clear Cell / chemistry
  • Sarcoma, Clear Cell / secondary*
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / pathology*
  • Transcription Factors / analysis
  • Wrist

Substances

  • Antigens, Neoplasm
  • DNA Primers
  • DNA, Neoplasm
  • EWS-ATF1 fusion protein, human
  • Melanoma-Specific Antigens
  • Neoplasm Proteins
  • Oncogene Proteins, Fusion
  • Transcription Factors