Solitary fibrous tumor of the spinal nerve rootlet: case report and literature survey

Pathol Int. 1999 Sep;49(9):826-30. doi: 10.1046/j.1440-1827.1999.00946.x.

Abstract

Solitary fibrous tumor (SFT) is a rare tumor that arises most commonly in the pleura. Recent evidence indicated that it is a tumor that originates from mesenchymal, probably fibroblastic, cells and is not restricted to the pleura. This report presents a case of primary SFT occurring as a dumbbell-shaped tumor of the cervical spine (C4/5) in a 46-year-old Japanese female, probably originating from the spinal rootlet. The tumor was predominantly extradural, loosely attached to the dura mater, with a small intradural extramedullary part attached to the C5 anterior and posterior rootlets. Histologically, the tumor was predominantly composed of a haphazard proliferation of spindle cells separated by abundant collagen. Immunohistochemically, the cells were strongly positive for CD34, bcl-2 and vimentin, but were negative for S-100 protein, neuron specific enolase, cytokeratin and epithelial membrane antigen. The present case and review of the literature strongly suggest that SFT is an entity that should be considered in the differential diagnosis of tumors of the cerebrospinal region.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antigens, Nuclear
  • Biomarkers, Tumor / analysis
  • Cervical Vertebrae / pathology
  • Cervical Vertebrae / surgery
  • Female
  • Humans
  • Immunohistochemistry
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neoplasms, Fibrous Tissue / chemistry
  • Neoplasms, Fibrous Tissue / pathology*
  • Neoplasms, Fibrous Tissue / surgery
  • Nuclear Proteins / analysis
  • Spinal Neoplasms / chemistry
  • Spinal Neoplasms / pathology*
  • Spinal Neoplasms / surgery
  • Spinal Nerves / pathology*
  • Spinal Nerves / surgery

Substances

  • Antigens, Nuclear
  • Biomarkers, Tumor
  • Nuclear Proteins