The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

Nat Genet. 1999 Oct;23(2):144-6. doi: 10.1038/13776.
No abstract available

Publication types

  • Letter

MeSH terms

  • Animals
  • Cell Differentiation / genetics*
  • Ethylnitrosourea / adverse effects
  • Genetic Predisposition to Disease
  • Granulocytes / cytology*
  • Hematopoiesis / genetics
  • Leukemia, Myelomonocytic, Acute / chemically induced
  • Leukemia, Myelomonocytic, Acute / genetics*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Mutagens / adverse effects
  • Oncogene Proteins, Fusion / genetics*

Substances

  • CBFbeta-MYH11 fusion protein
  • Mutagens
  • Oncogene Proteins, Fusion
  • Ethylnitrosourea