Abstract
Recent cloning efforts have identified families of ligand- or voltage-gated ion channels that are expressed by pain-sensing primary afferent neurons. Pharmacological, electrophysiological and genetic studies are beginning to reveal how these signaling molecules specify roles for subsets of sensory neurons in the pain pathway.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acids / metabolism
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Adenosine Triphosphate / physiology
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Animals
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Electrophysiology
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Humans
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Ion Channel Gating
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Ion Channels / metabolism
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Nerve Endings / physiology
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Nociceptors / metabolism*
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Receptors, Drug / physiology
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Sodium Channels / physiology
Substances
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Acids
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Ion Channels
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Receptors, Drug
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Sodium Channels
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Adenosine Triphosphate