Abstract
Apparent diffusion coefficient maps of two patients with cyclosporine-induced neurotoxicity showed areas of increased diffusion that corresponded to the characteristic regions of signal change on routine T2-weighted sequences. The majority of lesions subsequently resolved without residual T2 or diffusion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of cyclosporine resulted in a partially reversible extravasation of fluid into the cerebral interstitium and were not associated with acute ischemia.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Anemia, Sickle Cell / drug therapy
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Bone Marrow Transplantation
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Brain / drug effects
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Brain / pathology
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Brain Mapping*
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Child
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Child, Preschool
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Cyclosporine / administration & dosage
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Cyclosporine / adverse effects*
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Diffusion
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Humans
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Image Processing, Computer-Assisted*
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Immunosuppressive Agents / adverse effects*
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Magnetic Resonance Imaging*
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Male
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Neurotoxicity Syndromes / diagnosis*
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Severe Combined Immunodeficiency / drug therapy
Substances
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Immunosuppressive Agents
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Cyclosporine