Abstract
New polyacetylenic alcohols with a C(45) carbon skeleton (2) and with an enone moiety in the alkyl chain (C(46), 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectral methods, and the absolute stereochemistry was determined by the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylene / analogs & derivatives*
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Acetylene / chemistry
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Acetylene / isolation & purification
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Acetylene / pharmacology
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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DNA Replication / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Marine Biology
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Molecular Structure
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Polymers / chemistry
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Polymers / isolation & purification*
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Polymers / pharmacology
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Polyynes
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Porifera / chemistry*
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Simian virus 40 / genetics
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Polymers
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Polyynes
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Acetylene