Abstract
An 11-residue peptide (FQWQRNMRKVR) homologous to just over half the loop region of human lactoferricin is thought to be responsible for antimicrobial properties of human lactoferricin. Multiple antigen peptides (MAP) of the 11-residue peptide exerted significant antibacterial effects against a broad spectrum of bacteria including MRSA. More than eight branching was favourable for increasing its antibacterial activity. Our report shows a novel possibility for MAP to increase the activity of antibiotic peptides other than simply to stimulate antibody production, as reported so far.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antigens / pharmacology*
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Apoproteins / chemistry
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Escherichia coli / drug effects
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Humans
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Lactoferrin / chemistry
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Lactoferrin / pharmacology*
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Models, Molecular
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Molecular Sequence Data
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Peptide Fragments / chemical synthesis
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Peptide Fragments / pharmacology*
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Peptides / chemical synthesis
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Peptides / pharmacology*
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Protein Conformation
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Protein Structure, Secondary
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Pseudomonas aeruginosa / drug effects
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Salmonella / drug effects
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antigens
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Apoproteins
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Peptide Fragments
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Peptides
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Lactoferrin