Abstract
Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Atrophy
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Bacterial Vaccines / immunology*
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Cholera Toxin / immunology
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Gastric Mucosa / pathology*
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Helicobacter / immunology*
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Helicobacter Infections / prevention & control*
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Immunity, Mucosal
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Immunization
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Mice
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Mice, Inbred BALB C
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Recombinant Proteins / immunology
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Urease / immunology*
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Vaccines, Synthetic / immunology*
Substances
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Bacterial Vaccines
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Recombinant Proteins
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Vaccines, Synthetic
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Cholera Toxin
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Urease