The results of treatment (in Hospital N.N. Burdenko) of 167 patients with anaerobic nonsporeforming ("nonclostridial") infection of soft tissues (ANIST) of various location are presented. Principal errors of intensive care in this category of patients, substantial difference in the course of infectious process in patients with ANIST depending the diseased area are shown. Programs of treatment for the patients with limited (up to 1600 cm2) and extended (over 1600 cm2) forms of ANIST are proposed. The effectiveness of such components of intensive care as ozonotherapy, correction of metabolic disturbances, HBO has been studied. Practical application of these programs allowed active influence on intoxication syndrome in ANIST which resulted in a decrease of lethality up to 10.2%.