Abstract
lisRK encodes a two-component regulatory system in the food pathogen Listeria monocytogenes LO28. Following identification of the operon in an acid-tolerant Tn917 mutant, a deletion in the histidine kinase component was shown to result in a growth phase variation in acid tolerance, an ability to grow in high ethanol concentrations, and a significant reduction in virulence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Colony Count, Microbial
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Gene Deletion*
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Genes, Bacterial
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Heat-Shock Response
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Histidine Kinase
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Listeria monocytogenes / genetics
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Listeria monocytogenes / growth & development*
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Listeria monocytogenes / pathogenicity*
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Listeriosis / microbiology*
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Protein Kinases / genetics
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Signal Transduction / genetics*
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Virulence
Substances
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Bacterial Proteins
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Protein Kinases
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Histidine Kinase