Denaturing gradient gel electrophoresis-based analysis of loss of heterozygosity distinguishes nonobvious, deleterious BRCA1 variants from nonpathogenic polymorphisms

Clin Chem. 1999 Nov;45(11):2028-30.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • BRCA1 Protein / genetics*
  • Breast Neoplasms / chemistry
  • Breast Neoplasms / genetics
  • DNA, Neoplasm / analysis
  • Electrophoresis, Polyacrylamide Gel / methods
  • Female
  • Heterozygote
  • Humans
  • Lymphocytes / chemistry
  • Nucleic Acid Denaturation
  • Ovarian Neoplasms / chemistry
  • Ovarian Neoplasms / genetics
  • Polymerase Chain Reaction
  • Polymorphism, Genetic

Substances

  • BRCA1 Protein
  • DNA, Neoplasm