Hodgkin's disease in HIV-infected individuals

Curr Opin Oncol. 1999 Nov;11(6):522-6. doi: 10.1097/00001622-199911000-00015.

Abstract

The clinical and pathologic characteristics of Hodgkin's disease as they are diagnosed in patients with HIV infection differ from those of the general population. In fact, a higher frequency of unfavorable histologic subtypes, advanced stage, and poor therapeutic outcome have been reported in the HIV setting. Complete response rate after chemotherapy ranges from approximately 45% to 70%, although the disease-free survival is very short, and the median overall survival is only 18 months. The survival of these patients may be improved by the optimal combination of antineoplastic and antiretroviral treatment with the support of hematologic growth factors. However, new strategies of therapeutic intervention must be explored.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV Infections / epidemiology
  • HIV Infections / pathology
  • Hodgkin Disease / complications*
  • Hodgkin Disease / drug therapy
  • Hodgkin Disease / epidemiology
  • Hodgkin Disease / pathology
  • Humans