Abstract
GB virus C (GBV-C) markers were analyzed in two to three generations in three families with documented vertical transmission of GBV-C. None of the maternal grandparents had GBV-C markers, whereas the male spouses had GBV-C envelope 2 antibodies. Evidence was found for intrafamilial transmission but not for GBV-C transmission over three generations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Biomarkers
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Child
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Family
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Female
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Flaviviridae / genetics*
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Flaviviridae / immunology
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Flaviviridae / isolation & purification*
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Hepatitis, Viral, Human / transmission*
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Hepatitis, Viral, Human / virology
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Humans
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Infectious Disease Transmission, Vertical
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Male
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Middle Aged
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RNA, Viral / analysis
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RNA, Viral / blood
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Reverse Transcriptase Polymerase Chain Reaction
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Saliva / virology
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Viral Envelope Proteins / genetics
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Viral Envelope Proteins / immunology
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Viral Envelope Proteins / metabolism
Substances
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Biomarkers
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RNA, Viral
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Viral Envelope Proteins
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glycoprotein E2, GB virus C