Cerebral venous sinus thrombosis associated with hepatic cirrhosis

J Neurol Sci. 1999 Dec 1;171(1):65-8. doi: 10.1016/s0022-510x(99)00233-6.

Abstract

Cerebral venous sinus thrombosis is not a recognized complication of end-stage liver disease. A case of sagittal sinus thrombosis in a 44-year-old male with end-stage hepatic cirrhosis is described. Recurrent seizures were the only manifestation. Work-up revealed severe deficiency of protein C, protein S, and antithrombin III. He was treated with low molecular weight heparin and underwent an orthotopic liver transplant after three months. Follow-up helical CT venogram showed resolution of the sinus thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Coagulation Disorders / diagnosis
  • Blood Coagulation Disorders / drug therapy
  • Cerebral Veins / diagnostic imaging
  • Cerebral Veins / pathology*
  • Heparin, Low-Molecular-Weight / therapeutic use
  • Hepatitis C / complications
  • Humans
  • Liver Cirrhosis, Alcoholic / complications*
  • Liver Transplantation
  • Male
  • Phlebography
  • Sagittal Sinus Thrombosis / diagnosis*
  • Sagittal Sinus Thrombosis / diagnostic imaging
  • Sagittal Sinus Thrombosis / etiology*
  • Sagittal Sinus Thrombosis / therapy
  • Treatment Outcome

Substances

  • Heparin, Low-Molecular-Weight