Neuroleptic-induced extrapyramidal symptoms are accompanied by cognitive dysfunction in schizophrenia

Eur Psychiatry. 1999 Apr;14(2):84-8. doi: 10.1016/s0924-9338(99)80722-6.

Abstract

Cognitive impairments in schizophrenics have been found to precede tardive dyskinesia and to co-exist with other motor deficits. However, little is yet known about the prevalence of cognitive disturbances in patients with neuroleptic-induced parkinsonism. From the literature on idiopathic parkinson, it was inferred that extrapyramidal symptoms (EPS) are accompanied by cognitive dysfunction. 85 schizophrenic in-patients were divided into EPS high and low scorers according to an established criterion (Simpson Angus Scale, cut-off score: 0.4). Cognitive impairments were assessed using a self-rating instrument measuring disturbances of information processing. Patients with high EPS exhibited significantly elevated scores in six of ten cognitive and perceptual subscales (t = 2.1-3.1) as compared to low EPS patients. It is concluded that high EPS patients suffer from cognitive disturbances which are assumed to possess high relevance for both psycho-social and medical treatment. Cognitive problems may, when not considered, disturb compliance, insight of illness and transfer of learnt skills into everyday life.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects*
  • Basal Ganglia Diseases / complications
  • Basal Ganglia Diseases / diagnosis*
  • Brief Psychiatric Rating Scale
  • Cognition Disorders / diagnosis
  • Cognition Disorders / epidemiology
  • Cognition Disorders / etiology*
  • Depression / diagnosis
  • Female
  • Humans
  • Male
  • Prevalence
  • Schizophrenia / complications*
  • Schizophrenia / drug therapy*
  • Self-Assessment
  • Severity of Illness Index
  • Surveys and Questionnaires

Substances

  • Antipsychotic Agents