Abstract
We review the structure, cellular distribution, ligand specificity, and function of two emerging types of receptors involved in natural killer (NK) and myeloid cell recognition of other cells: ILT/LIR/MIR and 2B4 receptors. ILT/LIR/MIR receptors are differentially expressed on lymphoid and myeloid cells and two of them, ILT2 and ILT4, recognize HLA class I molecules. Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antigens, CD / immunology
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CD48 Antigen
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Cytokines / metabolism
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Cytoplasm
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Down-Regulation
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Histocompatibility Antigens Class I / immunology
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Humans
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Killer Cells, Natural / immunology*
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Leukocyte Immunoglobulin-like Receptor B1
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Membrane Glycoproteins / immunology
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Receptors, IgG / immunology
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Receptors, Immunologic / immunology*
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Signal Transduction*
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Signaling Lymphocytic Activation Molecule Family
Substances
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Antigens, CD
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CD244 protein, human
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CD48 Antigen
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CD48 protein, human
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Cytokines
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Histocompatibility Antigens Class I
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LILRB1 protein, human
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LILRB2 protein, human
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Leukocyte Immunoglobulin-like Receptor B1
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Membrane Glycoproteins
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Receptors, IgG
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Receptors, Immunologic
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Signaling Lymphocytic Activation Molecule Family