Abstract
Five new highly oxygenated bisabolane sesquiterpenes (1-5) were isolated from Cremanthodium discoideum. Their structures were elucidated on the basis of spectroscopic analysis and chemical transformations. The structure and relative stereochemistry of 1 were determined by single-crystal X-ray crystallography on the acetate derivative, 1a. Compound 1 showed antibacterial activity against Bacillus acidilatici and Bacillus subtilis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Asteraceae / chemistry*
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Bacillus / drug effects
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Bacillus subtilis / drug effects
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China
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Crystallography, X-Ray
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Microbial Sensitivity Tests
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Molecular Conformation
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plants, Medicinal / chemistry*
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Spectrometry, Mass, Fast Atom Bombardment
Substances
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Anti-Bacterial Agents
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Plant Extracts
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Sesquiterpenes