Abstract
Acute otitis media (AOM) is a common infectious disease in children. Some children experience recurrent episodes of AOM. Recent investigations demonstrate antigen-specific immunological deficiencies in children prone to AOM. In the present study, the immune responses to non-typeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (S. pneumoniae) were further investigated in otitis-prone children and normal children. Forty-eight percent of otitis-prone children exhibited reduced IgG2 levels to S. pneumoniae and 55% exhibited reduced IgG levels to NTHi. These data suggest that otitis proneness appears to be related to numerous immunological derangements. Pathogen-specific antibodies are a reliable measure of otitis proneness.
MeSH terms
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Acute Disease
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Antibodies, Bacterial / blood*
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Bacterial Capsules / immunology*
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Bacterial Outer Membrane Proteins / immunology*
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Bacterial Outer Membrane Proteins / isolation & purification
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Chi-Square Distribution
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Child, Preschool
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Disease Susceptibility / immunology
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Disease Susceptibility / microbiology
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Female
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Haemophilus Vaccines / immunology*
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Haemophilus Vaccines / isolation & purification
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Haemophilus influenzae / immunology*
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Haemophilus influenzae / isolation & purification
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Humans
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Immunoglobulin G / blood
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Infant
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Male
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Molecular Weight
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Otitis Media / immunology*
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Otitis Media / microbiology
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Polysaccharides, Bacterial / immunology*
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Streptococcus pneumoniae / immunology*
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Streptococcus pneumoniae / isolation & purification
Substances
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Antibodies, Bacterial
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Bacterial Outer Membrane Proteins
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Haemophilus Vaccines
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Immunoglobulin G
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P6 outer membrane protein, Haemophilus
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Polysaccharides, Bacterial