Abstract
There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMTH1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8-deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a useful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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8-Hydroxy-2'-Deoxyguanosine
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Biomarkers
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DNA Repair Enzymes*
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Deoxyguanosine / analogs & derivatives*
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Deoxyguanosine / analysis
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Humans
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Immunohistochemistry
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Mitochondria / enzymology*
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Mitochondria / pathology
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Models, Chemical
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Multiple System Atrophy / enzymology
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Neurons / enzymology*
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Neurons / pathology
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Oxidative Stress
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Parkinson Disease / enzymology*
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Parkinson Disease / pathology
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Phosphoric Monoester Hydrolases / metabolism*
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Reference Values
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Substantia Nigra / enzymology*
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Substantia Nigra / pathology
Substances
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Biomarkers
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8-Hydroxy-2'-Deoxyguanosine
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Phosphoric Monoester Hydrolases
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8-oxodGTPase
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DNA Repair Enzymes
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Deoxyguanosine