Abstract
We investigated the effect of BDNF mini-pellet on the GAP-43 mRNA expression and functional status of facial nerve in a rat model of facial nerve transection and immediate repair. The facial function started to recover at 17 days in the placebo group and 14 days in the BDNF group. BDNF group had shorter period of increased GAP-43 mRNA expression than the placebo group. Topically applied BDNF may accelerate the facial nerve regeneration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain-Derived Neurotrophic Factor / administration & dosage
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Brain-Derived Neurotrophic Factor / pharmacology*
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Collagen*
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Drug Carriers
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Facial Nerve / drug effects
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Facial Nerve / physiology*
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Facial Paralysis
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Female
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GAP-43 Protein / genetics*
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Nerve Regeneration / drug effects*
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Nerve Regeneration / physiology
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RNA, Messenger / genetics
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Rats
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Rats, Wistar
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Transcription, Genetic / drug effects*
Substances
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Brain-Derived Neurotrophic Factor
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Drug Carriers
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GAP-43 Protein
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RNA, Messenger
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atelocollagen
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Collagen