Retrograde amnesia and selective damage to the hippocampal formation: memory for places and object discriminations

Behav Brain Res. 1999 Dec;106(1-2):97-107. doi: 10.1016/s0166-4328(99)00097-2.

Abstract

Using a within-subjects design, rats were trained on two place-memory problems and five object-discrimination problems at different intervals prior to receiving either ibotenate lesions of the hippocampal formation or sham surgery. Places # 1 and 2 were fixed-platform water-maze tasks that were run in different rooms and they were learned during the 14th and 2nd week before surgery, respectively. Object-discrimination problems # 1-5 were learned during the 13th, 10th, 7th, 4th, and 1st week before surgery, respectively. Rats with hippocampal lesions displayed impaired retention of both Place problems with no evidence of a temporal gradient to the impairment. In contrast to their retrograde place-memory deficits, the hippocampal rats displayed normal retention of the five object-discriminations that were learned before surgery. Hippocampal lesions had similar consequences for anterograde learning, as the lesioned rats were impaired in acquisition of a new water-maze problem that was run in a third room (Place #3), whereas they showed normal acquisition of two new object-discriminations. The findings indicate that the hippocampal formation is not required for long-term consolidation of information underlying accurate performance of object-discriminations, and that its critical role in memory for places persists for at least 14 weeks, and probably for as long as those memories exist.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amnesia, Retrograde / chemically induced
  • Amnesia, Retrograde / psychology*
  • Animals
  • Dentate Gyrus / drug effects
  • Dentate Gyrus / physiology
  • Discrimination, Psychological / drug effects
  • Discrimination, Psychological / physiology*
  • Excitatory Amino Acid Agonists / toxicity
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • Ibotenic Acid / toxicity
  • Male
  • Memory / physiology*
  • Rats
  • Rats, Long-Evans

Substances

  • Excitatory Amino Acid Agonists
  • Ibotenic Acid