Limited functional grouping of neurons in the motor cortex hand area during individuated finger movements: A cluster analysis

J Neurophysiol. 1999 Dec;82(6):3488-505. doi: 10.1152/jn.1999.82.6.3488.

Abstract

Primary motor cortex (M1) hand area neurons show patterns of discharge across a set of individuated finger and wrist movements so diverse as to preclude classifying the neurons into functional groups on the basis of simple inspection. We therefore applied methods of cluster analysis to search M1 neuronal populations for groups of neurons with similar patterns of discharge across the set of movements. Populations from each of three monkeys showed a large group of neurons the discharge of which increased for many or all of the movements and a second small group the discharge of which decreased for many or all movements. Two to three other small groups of neurons that discharged more specifically for one or two movements also were found in each monkey, but these groups were less consistent than the groups with broad movement fields. The limited functional grouping of M1 hand area neurons suggests that M1 neurons act as a network of highly diverse elements in controlling individuated finger movements.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Animals
  • Cluster Analysis
  • Electric Stimulation
  • Electromyography
  • Evoked Potentials / physiology
  • Fingers / innervation*
  • Fingers / physiology
  • Hand / innervation*
  • Hand / physiology
  • Macaca mulatta
  • Male
  • Microelectrodes
  • Motor Cortex / cytology*
  • Movement / physiology*
  • Neurons / physiology*