Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors

J Neurophysiol. 1999 Dec;82(6):3594-7. doi: 10.1152/jn.1999.82.6.3594.

Abstract

We tested the role of group I mGluRs in the induction of long-term depression (LTD) in the visual cortex, using the novel mGluR antagonist LY341495 and mice lacking mGluR5, the predominant phosphoinositide (PI)-linked mGluR in the visual cortex. We find that LY341495 is a potent blocker of glutamate-stimulated PI hydrolysis in visual cortical synaptoneurosomes, and that it effectively antagonizes the actions of the mGluR agonist 1S, 3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on synaptic transmission in visual cortical slices. However, LY341495 has no effect on the induction of LTD by low-frequency stimulation. Furthermore, mice lacking mGluR5 show normal NMDA receptor-dependent LTD. These results indicate that group I mGluR activation is not required for the induction of NMDA receptor-dependent LTD in the visual cortex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids / pharmacology
  • Animals
  • Cycloleucine / analogs & derivatives
  • Cycloleucine / pharmacology
  • Depression, Chemical
  • Excitatory Amino Acid Antagonists / pharmacology
  • Hydrolysis
  • In Vitro Techniques
  • Methoxyhydroxyphenylglycol / analogs & derivatives
  • Methoxyhydroxyphenylglycol / pharmacology
  • Mice
  • Mice, Knockout
  • Neuronal Plasticity / drug effects
  • Neuronal Plasticity / physiology*
  • Phosphatidylinositols / metabolism
  • Rats
  • Receptors, Metabotropic Glutamate / agonists
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors
  • Receptors, Metabotropic Glutamate / physiology*
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Receptors, N-Methyl-D-Aspartate / genetics
  • Receptors, N-Methyl-D-Aspartate / physiology*
  • Synaptosomes / drug effects
  • Synaptosomes / metabolism
  • Visual Cortex / drug effects
  • Visual Cortex / physiology*
  • Xanthenes / pharmacology

Substances

  • Amino Acids
  • Excitatory Amino Acid Antagonists
  • LY 341495
  • Phosphatidylinositols
  • Receptors, Metabotropic Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • Xanthenes
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
  • Methoxyhydroxyphenylglycol
  • 3,4-dihydroxyphenylglycol