Minocycline-induced clinical and biological lupus-like disease

Lupus. 1999;8(9):773-4. doi: 10.1191/096120399678841025.

Abstract

A 14-year-old girl developed maculopapular rash, myalgias, arthralgias and myocarditis with elevated anti-nuclear and anti-double-stranded DNA antibodies. She was taking minocycline for acne and all symptoms resolved when this treatment was stopped. The patient has no evidence of disease one year after onset of symptoms. Clinicians should be aware of minocycline's responsibility in inducing lupus-like disease.

Publication types

  • Case Reports

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Adolescent
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Antibodies, Antinuclear / immunology
  • Female
  • Humans
  • Lupus Vulgaris / chemically induced*
  • Lupus Vulgaris / immunology
  • Lupus Vulgaris / physiopathology
  • Minocycline / adverse effects*
  • Minocycline / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Antibodies, Antinuclear
  • Minocycline