Abstract
Cryptococcus neoformans is the causative agent of cryptococcosis and cryptococcal meningitis, which are serious pathological conditions affecting up to 10% of patients with AIDS. Mechanisms of pathogenicity of C. neoformans and the host defenses against this fungus are reviewed, incorporating recent data and perspectives.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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AIDS-Related Opportunistic Infections / immunology
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AIDS-Related Opportunistic Infections / microbiology
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Animals
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Brain / microbiology
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Cryptococcosis / immunology*
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Cryptococcosis / microbiology*
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Cryptococcus neoformans / immunology
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Cryptococcus neoformans / pathogenicity*
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Cryptococcus neoformans / physiology
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Humans
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Immunocompromised Host
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Meningitis, Cryptococcal / microbiology
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Pulmonary Alveoli / microbiology
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Signal Transduction
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Virulence