Diffusion-weighted MRI in cyclosporin A neurotoxicity for the classification of cerebral edema

C Debaere; T Stadnik; M De Maeseneer; M Osteaux

doi:10.1007/s003300050948

Diffusion-weighted MRI in cyclosporin A neurotoxicity for the classification of cerebral edema

Eur Radiol. 1999;9(9):1916-8. doi: 10.1007/s003300050948.

Authors

C Debaere¹, T Stadnik, M De Maeseneer, M Osteaux

Affiliation

¹ Department of Radiology, Academic Hospital, Vrije Universiteit Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium.

PMID: 10602976
DOI: 10.1007/s003300050948

Abstract

Cyclosporin A, an immunosuppressive agent, is known to have neurotoxic effects, but until now, there has not been agreement on the underlying mechanism. Our report suggests, by using diffusion-weighted MRI, that the brain lesions caused by cyclosporin A, are probably related to vasogenic edema. This may explain the complete recovery of the lesions on imaging when cyclosporine therapy is stopped.

Publication types

Case Reports

MeSH terms

Adult
Bone Marrow Transplantation
Brain / drug effects
Brain / pathology*
Brain Edema / chemically induced
Brain Edema / classification*
Brain Edema / diagnosis
Cyclosporine / adverse effects*
Diffusion
Graft vs Host Disease / prevention & control
Humans
Immunosuppressive Agents / adverse effects*
Magnetic Resonance Imaging / methods*
Male
Neurotoxicity Syndromes / classification
Neurotoxicity Syndromes / complications
Neurotoxicity Syndromes / diagnosis*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy

Substances

Immunosuppressive Agents
Cyclosporine