A genetic dissection of the retinoid signalling pathway in the mouse

M Mark; N B Ghyselinck; O Wendling; V Dupé; B Mascrez; P Kastner; P Chambon

doi:10.1017/s0029665199000798

A genetic dissection of the retinoid signalling pathway in the mouse

Proc Nutr Soc. 1999 Aug;58(3):609-13. doi: 10.1017/s0029665199000798.

Authors

M Mark¹, N B Ghyselinck, O Wendling, V Dupé, B Mascrez, P Kastner, P Chambon

Affiliation

¹ Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, C.U. de Strasbourg, France.

PMID: 10604193
DOI: 10.1017/s0029665199000798

Abstract

To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the embryonic stem cells and generated null-mutant mice. This approach has allowed us to perform a genetic dissection of the retinoic acid signalling pathway.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Mice
Mice, Knockout
Receptors, Retinoic Acid / genetics
Receptors, Retinoic Acid / physiology
Retinoid X Receptors
Retinoids*
Signal Transduction / genetics*
Transcription Factors / genetics
Transcription Factors / physiology

Substances

Receptors, Retinoic Acid
Retinoid X Receptors
Retinoids
Transcription Factors