Influence of foscarnet on HIV-associated Kaposi's sarcoma derived cell lines

Eur J Med Res. 1999 Dec 16;4(12):514-6.

Abstract

Recent reports showed a positive therapeutic effect of foscarnet on Kaposi's sarcoma (KS) in HIV-positive patients. We investigated the therapeutic effect of foscarnet on KS-derived cell lines. Three KS spindle cell cultures of HIV-positive patients as well three fibroblast cell cultures of HIV-positive as HIV-negative patients were established. The influence of different foscarnet concentrations (50, 100, 200, 400, 600, 1000 microg/ml) on these cell lines were analysed. There was no significant change in fibroblast cell numbers suggesting that there is neither a proliferative nor an antiproliferative effect of foscarnet on these cell lines. Furthermore, incubation of the three KS-derived cell lines of HIV-positive patients with different foscarnet concentrations did not change KS-cell number significantly.

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cell Division / drug effects
  • Fibroblasts / drug effects
  • Foscarnet / pharmacology*
  • HIV Infections / complications*
  • Herpesvirus 8, Human
  • Humans
  • Sarcoma, Kaposi / complications*
  • Sarcoma, Kaposi / drug therapy*
  • Tumor Cells, Cultured

Substances

  • Antiviral Agents
  • Foscarnet