Abstract
We performed a retrospective study based on chart review of 118 HIV-infected patients with culture-confirmed pulmonary TB, in which M. tuberculosis isolates were tested for drug susceptibility. Patients were enrolled in the period January 1987 to December 1996 and followed until September 1997. The median survival for the entire cohort was 15.2 months with a 1-year survival rate of 57%. Prior AIDS-defining illness, low CD4 count (< 200/mm3), not having received antituberculous therapy with at least two drugs to which M. tuberculosis was susceptible in vitro, starting within four weeks of diagnosis, treatment duration of less than three weeks and multidrug resistant tuberculosis were each independently associated with decreased survival in multivariate analysis.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
AIDS-Related Opportunistic Infections / diagnosis
-
AIDS-Related Opportunistic Infections / drug therapy
-
AIDS-Related Opportunistic Infections / mortality
-
Acquired Immunodeficiency Syndrome / immunology
-
Acquired Immunodeficiency Syndrome / microbiology*
-
Acquired Immunodeficiency Syndrome / mortality*
-
Adult
-
Antibiotics, Antitubercular / pharmacology
-
Antibiotics, Antitubercular / therapeutic use
-
Antitubercular Agents / pharmacology
-
Antitubercular Agents / therapeutic use
-
CD4 Lymphocyte Count
-
Drug Resistance, Microbial
-
Drug Resistance, Multiple
-
Female
-
HIV Infections / immunology
-
HIV Infections / microbiology*
-
HIV Infections / mortality*
-
Humans
-
Isoniazid / pharmacology
-
Isoniazid / therapeutic use
-
Longitudinal Studies
-
Male
-
Mycobacterium tuberculosis / drug effects
-
Prognosis
-
Retrospective Studies
-
Rifampin / pharmacology
-
Rifampin / therapeutic use
-
Risk Factors
-
Time Factors
-
Tuberculosis, Pulmonary / diagnosis*
-
Tuberculosis, Pulmonary / drug therapy
Substances
-
Antibiotics, Antitubercular
-
Antitubercular Agents
-
Isoniazid
-
Rifampin