The HIV protease inhibitors saquinavir, ritonavir, and nelfinavir but not indinavir impair the epithelial barrier in the human intestinal cell line HT-29/B6

AIDS. 1999 Dec 24;13(18):2595-7. doi: 10.1097/00002030-199912240-00016.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • HIV Protease Inhibitors / pharmacokinetics
  • HIV Protease Inhibitors / toxicity*
  • HT29 Cells
  • Humans
  • Indinavir / pharmacokinetics
  • Indinavir / toxicity
  • Intestinal Mucosa / cytology
  • Intestinal Mucosa / metabolism*
  • Ion Transport
  • Nelfinavir / pharmacokinetics
  • Nelfinavir / toxicity
  • Ritonavir / pharmacokinetics
  • Ritonavir / toxicity
  • Saquinavir / pharmacokinetics
  • Saquinavir / toxicity

Substances

  • HIV Protease Inhibitors
  • Indinavir
  • Nelfinavir
  • Saquinavir
  • Ritonavir